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one-north: Fostering Research, Innovation and Entrepreneurship chronicles the genesis, planning and development of one-north. A key element of Singapore’s Technopreneurship 21 initiative, one-north provides an intellectually stimulating and creative environment to attract world-class research talent and investments to drive the next phase of the country’s development. Planned as a work, live, play and learn environment, the innovation district symbolises Singapore’s response to changing economic circumstances and its transformation into a knowledge economy. This study examines the development of Biopolis, Fusionopolis and Mediapolis as clusters for industries in biomedical sciences, info-communications technology and media, supported by capabilities in science and engineering.